반응 #63465

반응 방정식

Methyl 4-(3,4-dihydro-4-methyl-3-oxo-1,4[2H]-benzothiazin-7-yl)-4-oxo-3-methylbutyrate

hydrazine

→

named compound

6-(3,4-Dihydro-4-methyl-3-oxo-1,4[2H]-benzothiazin-7-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one

용매

ethanol

반응 조건

후처리

1. 1
   여과Filtration
2. 2
   기타gave a white powder which
3. 3
   기타was chromatographed on silica gel
4. 4
   세척eluted with 5% methanol in methylene chloride

실험 절차

Methyl 4-(3,4-dihydro-4-methyl-3-oxo-1,4[2H]-benzothiazin-7-yl)-4-oxo-3-methylbutyrate (1.7 g) was heated at reflux overnight with 0.3 ml of hydrazine in 50 ml of ethanol. Filtration gave a white powder which was chromatographed on silica gel eluted with 5% methanol in methylene chloride, yielding 110 mg of the named compound, mp 193°-194.5° C.

출처