반응 #634624

반응 방정식

4-methylpyrimidine

N,N-dimethylformamide dimethylacetal

→

title compound

수율 95.1%

dimethyl-[(E)-2-(4-pyrimidinyl)vinyl]amine

수율 95.1%

용매

DMF

반응 조건

후처리

1. 1
   온도The reaction solution was cooled
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

실험 절차

A mixture of 10 g of 4-methylpyrimidine, 38 g of N,N-dimethylformamide dimethylacetal (DMFDMA) and 46.6 g of DMF was stirred in a sealed tube at 140° C. for 24 hours. The reaction solution was cooled and the solvent was distilled off under reduced pressure to provide 15.08 g (yield: 95%) of the title compound as brown crystal.

출처