반응 #63451
ord-ec01c07dd42e42d19e85933e8284aee8
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과a small amount of the hydrobromide salt of the still unreacted azepine is filtered off
- 2세척The filtrate is washed three times with water
- 3건조dried over anhydrous sodium sulphate
- 4기타evaporated
실험 절차
A solution of 1.91 g of cyanogen bromide in 20 ml of chloroform is added dropwise at 5°-10° C. within 25 minutes to a solution, cooled to 5° C., of 7 g of 6,7-dihydro-5H-dibenz[c,e]azepine in 50 ml of chloroform. The reaction mixture is stirred for a further 1 hour and then a small amount of the hydrobromide salt of the still unreacted azepine is filtered off. The filtrate is washed three times with water, dried over anhydrous sodium sulphate and evaporated. There is obtained solid 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile, m.p. 123°-126° C.