반응 #6345

반응 방정식

4,6-dichloro-2,5-diformamidopyrimidine

diethyl [2-acetoxy-1-(aminooxymethyl)ethoxy)methylphosphonate

triethylamine

→

title compound

수율 81.4%

6-[[3-Acetoxy-2-(diethoxyphosphorylmethoxy)propoxy]amino]-4-chloro-2,5-diformamidopyrimidine

수율 81.4%

용매

dioxan

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled to ambient temperature
2. 2
   여과filtered
3. 3
   기타the filtrate evaporated
4. 4
   기타to leave a yellow oil
5. 5
   기타The oil was chromatographed on silica gel (eluant dichloromethane:methanol 97:3)

실험 절차

A mixture of 4,6-dichloro-2,5-diformamidopyrimidine (0.475 mg, 2 mmol), diethyl [2-acetoxy-1-(aminooxymethyl)ethoxy)methylphosphonate (0.60 mg, 2 mmol) and triethylamine (0.54 ml, 4 mmol) in dry dioxan (20 ml) was heated at 120° C. for 5 hours. The reaction mixture was cooled to ambient temperature, filtered, and the filtrate evaporated to leave a yellow oil. The oil was chromatographed on silica gel (eluant dichloromethane:methanol 97:3) to give the title compound as a pale yellow solid (0.81 g, 80%). 1H NMR: δH [(CD3)2SO] 1.23 (2×3H, 2×t, J=7 Hz, (OCH2CH3)2), 2.03 (3H,s, COCH3), 3.80-4.35 (11H,m, CH2CHCH2 +(OCH2CH3)2 +OCH2P), 8.16 (1H,br.s, sharpens to s. on D2O, CHO), 9.26 (1H,d,J=9.9 Hz. collapses to s. on D2O. CHO), 9.45 (1H,br.s, D2O exchangeable, NH), 10.8-10.95 (2H,m, D2O exchangeable 2×NH). Found: C,37.36; H,5.37; N,13.43%; C16H25N5O9PCl.H2O requires: C,37.18; H,5.27; N,13.55%. m/z: observed 497.1082; C16H25N5O9PCl(M+) requires 497.1078.

출처