반응 #63424

반응 방정식

cyano-phenol

diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate

potassium carbonate

→

desired compound

수율 86.0%

diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate

수율 86.0%

용매

dimethyl sulfoxide

반응 조건

후처리

1. 1
   workup.ADDITIONare added
2. 2
   여과The reaction mixture is filtered
3. 3
   기타the filtrate is evaporated

실험 절차

11.9 g of cyano-phenol and 32.6 g of diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate are dissolved in 150 ml of dimethyl sulfoxide, whereupon 13.8 g of potassium carbonate are added and the reaction mixture is stirred at 60° C. for 6 hours. The reaction mixture is filtered and the filtrate is evaporated. Thus 36 g of the desired compound are obtained, yield 86%.

출처