반응 #63423

반응 방정식

diethyl malonate

magnesium diethyl malonate

2-[-4'-(4"-cyano-phenoxy)-phenoxy]-propionyl chloride

→

desired compound

수율 72.0%

diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate

수율 72.0%

용매

ether

반응 조건

후처리

1. 1
   온도is heated
2. 2
   workup.WAITto boiling for an hour

실험 절차

A mixture of 30 g of 2-[-4'-(4"-cyano-phenoxy)-phenoxy]-propionyl chloride and 30 ml of ether is added dropwise to a 35% etheral solution of magnesium diethyl malonate prepared from 17.6 g of diethyl malonate. The addition of the acid chloride having been completed the reaction mixture is heated to boiling for an hour and worked up as described in Example 1. Thus 30 g of the desired compound are obtained in the form of a viscous oil which solidifies on standing and melts at 42°-46° C. Yield 72%.

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