반응 #63366

반응 방정식

n-butyl bromide

sodium hydride

1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

→

3-n-butyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

용매

N,N-dimethylformamide

N,N-dimethylformamide

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONare then added dropwise
2. 2
   기타The residue is partitioned between ethyl acetate and water
3. 3
   건조the organic phase is dried over magnesium sulphate
4. 4
   농축after concentration
5. 5
   기타by evaporation and subsequent recrystallisation from ethyl acetate/petroleum ether
6. 6
   기타the product is obtained

실험 절차

0.36 g of sodium hydride is added to a solution of 2.46 g of 1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 25 ml of N,N-dimethylformamide and the whole is stirred at room temperature for 30 minutes. 1.6 ml of n-butyl bromide dissolved in 10 ml of N,N-dimethylformamide are then added dropwise thereto. When the reaction is complete, the reaction mixture is freed of N,N-dimethylformamide. The residue is partitioned between ethyl acetate and water, and the organic phase is dried over magnesium sulphate and, after concentration by evaporation and subsequent recrystallisation from ethyl acetate/petroleum ether, the product is obtained having a melting point of 120°-123°.

출처