반응 #633433

반응 방정식

5-bromomethyl-benzo[b]thiophene

sodium cyanide

N,N-dimethylformamide

→

benzo[b]thiophen-5-yl-acetonitrile

수율 55.0%

용매

water

반응 조건

후처리

1. 1
   기타In a round bottom flask was placed
2. 2
   추출extracted with ethyl acetate (3×30 mL)
3. 3
   건조dried over sodium sulfate
4. 4
   기타purified on an AnaLogix Intelliflash system (120 g column, 3% ethyl acetate/hexanes to 20% ethyl acetate/hexanes)

실험 절차

In a round bottom flask was placed 5-bromomethyl-benzo[b]thiophene (5.27 g, 23.20 mmol), sodium cyanide (1.59 g, 32.49 mmol) and N,N-dimethylformamide (50 mL) and it was stirred for 24 h at 25° C. After this time, the reaction mixture was dissolved in water (30 mL) and extracted with ethyl acetate (3×30 mL), dried over sodium sulfate and purified on an AnaLogix Intelliflash system (120 g column, 3% ethyl acetate/hexanes to 20% ethyl acetate/hexanes) to afford benzo[b]thiophen-5-yl-acetonitrile (2.23 g, 55%) as a yellow solid.

출처