반응 #632010

반응 방정식

N-tert-butyl-(1-methyl)cyclopropylsulfonamide

methyl benzoate

→

N-tert-butyl-(1-benzoyl)cyclopropyl-sulfonamide

수율 66.0%

반응 조건

후처리

1. 1
   기타This compound was obtained in 66% yield
2. 2
   기타The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane

실험 절차

This compound was obtained in 66% yield using the procedure described for the synthesis of N-tert-butyl-(1-methyl)cyclopropylsulfonamide using 1.2 equivalents of methyl benzoate as the electrophile. The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane: 1H NMR (CDCl3) δ 1.31 (s, 9H), 1.52 (m, 2H), 1.81 (m, 2H), 4.16 (br s, 1H), 7.46 (m, 2H), 7.57 (m, 1H), 8.05 (d, J=8.5 Hz, 2H).

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