반응 #63186

반응 방정식

2-(4-oxo-3-thiazolidinyl)propionic acid

2.6-dimethylaniline

dicyclohexylcarbodiimide

→

N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide

수율 45.7%

용매

chloroform

반응 조건

후처리

1. 1
   온도was refluxed for 48 hours
2. 2
   기타The resultant precipitate was removed by filtration
3. 3
   기타the filtrate was evaporated in vacuo
4. 4
   기타The residue was triturated with diethyl ether
5. 5
   기타recrystallized from ethanol

실험 절차

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

출처