반응 #63180

반응 방정식

2-Bromopropionyl bromide

3,4-dihydro-3-methyl-2(1H)quinazolinone

aluminum chloride

→

6-(2-bromopropionyl)-3,4,dihydro-3-methyl-2(1H)-quinazolinone

용매

carbon disulfide

반응 조건

후처리

1. 1
   온도under reflux for 5 hrs
2. 2
   기타, the carbon disulfide decanted
3. 3
   workup.ADDITIONthe residue treated with HCl (6N)
4. 4
   여과The resulting solid is filtered
5. 5
   세척washed with water
6. 6
   기타dried in vacuo

실험 절차

2-Bromopropionyl bromide (71.02 g) is added dropwise to a stirred mixture of 3,4-dihydro-3-methyl-2(1H)quinazolinone (26.75 g) and anhydrous aluminum chloride (54.98 g) in carbon disulfide (350 ml). The reaction mixture is stirred under reflux for 5 hrs., the carbon disulfide decanted, and the residue treated with HCl (6N). The resulting solid is filtered, and washed with water and dried in vacuo to obtain 6-(2-bromopropionyl)-3,4,dihydro-3-methyl-2(1H)-quinazolinone which is used in the next step.

출처