반응 #6317

반응 방정식

hydrochloric acid

2-aminobenzonitrile

cyclohexanone

hydrochloric acid

→

9-amino-1,2,3,4-tetrahydroacridine hydrate

수율 67.0%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 3 days
3. 3
   기타The precipitate was collected
4. 4
   세척washed with 10% hydrochloric acid

실험 절차

A mixture of 2-aminobenzonitrile (120 g), cyclohexanone (115.8 ml), conc hydrochloric acid (9.2 ml), and cuprous chloride (1.21 g) was heated under reflux for 3 days, with stirring. At the end of each 24 hr period, additional cuprous chloride (1.21 g) was added. At the end of the 3rd day, additional conc hydrochloric acid (47.3 ml) was added, and the mixture was cooled to ambient temperature. The precipitate was collected and washed with 10% hydrochloric acid to provide 160 g (67.0%) of 9-amino-1,2,3,4-tetrahydroacridine hydrate, mp 180°-185°.

출처