반응 #631670

반응 방정식

1-(2-quinolinyl)piperazine

ethyl isothiocyanate

→

desired product

N-Ethyl-4-(2-quinolyl)-1-piperazinethiocarboxamide

용매

ether

반응 조건

후처리

1. 1
   workup.ADDITIONof anhydrousether is added dropwise a solution of 1.74 g
2. 2
   기타the resulting solid is collected
3. 3
   기타recrystallized from 150 ml
4. 4
   기타of ethanol, giving 4.43 g

실험 절차

To a slurry of 4.26 g. of 1-(2-quinolinyl)piperazine in 30 ml. of anhydrousether is added dropwise a solution of 1.74 g. of ethyl isothiocyanate in 30ml. of anhydrous ether. The mixture is stirred for one hour and the resulting solid is collected and recrystallized from 150 ml. of ethanol, giving 4.43 g. of the desired product as a white crystalline solid, m.p. 193°-195° C.

출처