반응 #63140

반응 방정식

2-amino-4-methoxy-6-methylpyrimidine

4-chlorothiophenol

formaldehyde

acetic acid

→

2-[(4-chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine

용매

methanol

반응 조건

후처리

1. 1
   온도are heated
2. 2
   여과The resultant solution is clarified by filtration
3. 3
   workup.ADDITIONdiluted with 150 ml of toluene
4. 4
   기타the solvent is removed in a rotary evaporator
5. 5
   기타The residue crystallises
6. 6
   기타The melting point is 78°-82° after recrystallisation from hexane

실험 절차

A mixture of 13.99 g of 2-amino-4-methoxy-6-methylpyrimidine (0.1 mole), 14.8 g of 4-chlorothiophenol (0.1 mole), 9.4 g of aqueous 35% formaldehyde (0.11 mole) and 1 g of acetic acid are heated under reflux for 1 hour in 100 ml of methanol. The resultant solution is clarified by filtration, diluted with 150 ml of toluene and then the solvent is removed in a rotary evaporator. The residue crystallises after standing for some time. The melting point is 78°-82° after recrystallisation from hexane. The yield is 24 g (81% of theory).

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