반응 #63131

반응 방정식

hydrochloric acid

3-tetradecylphenol

acetate

aluminum chloride

→

desired compound

1-(2-Hydroxy-4-tetradecylphenyl)ethanone

용매

ether

반응 조건

후처리

1. 1
   온도to cool
2. 2
   추출extracted several times with ether
3. 3
   세척washed with water, brine
4. 4
   기타dried
5. 5
   기타The crude material was chromatographed on silica gel
6. 6
   세척eluting with hexane:ethyl acetate (50:1)

실험 절차

A 20 g portion of 3-tetradecylphenol, acetate was heated at 110° C. and 8.4 g of aluminum chloride was added in portions over a 3 hour period. The mixture was allowed to cool, then diluted with ether, poured onto ice containing 10 ml of concentrated hydrochloric acid and extracted several times with ether. The ether extracts were combined, washed with water, brine and dried. The crude material was chromatographed on silica gel, eluting with hexane:ethyl acetate (50:1), giving 15.8 g of the desired compound, mp 45°-46° C.

출처