반응 #630547

ord-9f2bf8faa2b04c1fb43a61988fdfed31

반응 방정식

O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CCCC[C@H]1C(=O)O
cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylic acid
CO.[Na+].[OH-]
NaOH methanol
→
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CCCC[C@H]1C(=O)[O-].[Na+]
sodium cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylate

반응물

O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CCCC[C@H]1C(=O)O
cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylic acid
CO.[Na+].[OH-]
NaOH methanol

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The solvent was evaporated off to dryness

실험 절차

10 m Mol of cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylic acid was dissolved in 100 ml of 0.1N NaOH/methanol solution. The solvent was evaporated off to dryness to give sodium cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylate [melting point: 259°-260° C. (decomposition)].

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04661630uspto-grants-1987_04