반응 #630093

ord-0dabe3162f394c3c9bfcf7d27151ad10

반응 방정식

CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O
ceftazidime
→
CC(C)(O/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O.O.O.O.O.O
ceftazidime pentahydrate

반응물

CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O
ceftazidime

시약

없음

용매

O=CO
formic acid

반응 조건

온도
5°CELSIUS
상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    온도above was cooled
  2. 2
    기타The stirred solution was seeded with ceftazidime pentahydrate crystals and crystallization
  3. 3
    여과After 5 hours the crystals were harvested by filtration
  4. 4
    세척washed with 150 ml of chilled water and 100 ml of chilled acetone and air
  5. 5
    기타dried

실험 절차

A second 128 ml aliquot of the ceftazidime solution prepared as described above was cooled and maintained at 5° C., while the pH was adjusted from 5.8 to 3.6 with 10.5 ml of 5.9M formic acid. The stirred solution was seeded with ceftazidime pentahydrate crystals and crystallization commenced. After 5 hours the crystals were harvested by filtration, washed with 150 ml of chilled water and 100 ml of chilled acetone and air dried to give 20.8 g of ceftazidime pentahydrate. The material assayed as follows: HPLC potency 84.4% (as is); polymer (stressed material) 0.66%; related substances, 1.07%; Karl Fischer 14.1%.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04659813uspto-grants-1987_04