반응 #62989

반응 방정식

1-(2-furanylcarbonyl)-4-(2-chloroethyl)piperazine

sodium iodide

methylamine

→

crystals

수율 82.0%

N-methyl-N-[2-(4-(2-furanylcarbonyl)- 1-piperazinyl)ethyl]amine

수율 82.0%

용매

methanol

반응 조건

후처리

1. 1
   기타was reacted at 70° C. in a sealed tube for 24 hours
2. 2
   온도to cool down
3. 3
   농축the reaction mixture was concentrated under reduced pressure
4. 4
   기타the residue was purified by column chromatography on silica gel (eluent
5. 5
   workup.ADDITIONa 20:1:0.1 mixture of chloroform, methanol, and methanol containing 40% methylamine)

실험 절차

A solution of 1.0 g of 1-(2-furanylcarbonyl)-4-(2-chloroethyl)piperazine and 200 mg of sodium iodide in 40 ml of methanol which contained 25% of methylamine was reacted at 70° C. in a sealed tube for 24 hours. After allowing the reaction mixture to cool down, the reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: a 20:1:0.1 mixture of chloroform, methanol, and methanol containing 40% methylamine) to give 800 mg of crystals (yield: 82%).

출처