반응 #62983

반응 방정식

4-Trifluoromethylphenylisocyanate

amine

4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-hydroxy-7-amino-1,4-benzoxazine-3-one

→

( h )

4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-hydroxy-7-(4-trifluoromethylphenylureido)-1,4-benzoxazine-3-one

용매

THF

반응 조건

후처리

1. 1
   기타the solution was evaporated to dryness
2. 2
   기타the residue crystallized from toluene

실험 절차

4-Trifluoromethylphenylisocyanate (2.55 g, 0.0136 mole) was added to the amine ((g), 6.56 g, 0.0136 mole) in THF (ml 100). After 1 hour stirring, the solution was evaporated to dryness and the residue crystallized from toluene to give the coupler ((h), 6 g, 67%) as white prisms. The product structure was confirmed by NMR analysis.

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