반응 #62982

ord-ea4052d7a95f44e4b5f1ed5285bed7eb

반응 방정식

CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc([N+](=O)[O-])c(OCc3ccccc3)cc21
nitro
CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc([N+](=O)[O-])c(OCc3ccccc3)cc21
4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-benzyloxy-7-nitro-1,4-benzoxazine-3-one
[H][H]
hydrogen
→
CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc(N)c(O)cc21
amine
CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc(N)c(O)cc21
4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-hydroxy-7-amino-1,4-benzoxazine-3-one

반응물

CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc([N+](=O)[O-])c(OCc3ccccc3)cc21
nitro
CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)N1C(=O)COc2cc([N+](=O)[O-])c(OCc3ccccc3)cc21
4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-benzyloxy-7-nitro-1,4-benzoxazine-3-one
[H][H]
hydrogen

시약

[Pd]
Pd on charcoal

용매

C1CCOC1
THF

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The nitro compound ((f), 8.19 g, 0.0136 mole) in THF (ml 100) was reduced and debenzylated under 25 PSI hydrogen pressure at room temperature in the presence of 10% Pd on charcoal. The resulting amine (g) was not isolated.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04762925uspto-grants-1988_08