반응 #62974

반응 방정식

α-chloroacetylchloride

2-aminohydroquinone

diethanolamine

hydrochloride

→

2-(α-chloroacetamido)-hydroquinone

용매

acetone

water

반응 조건

후처리

1. 1
   추출extracted with ethylacetate (500 ml)
2. 2
   기타The solvent was evaporated to dryness
3. 3
   기타the solid residue (4.20 g, 80%) was used without any further purification

실험 절차

α-chloroacetylchloride (10.1 g, 0.128 mole) was added dropwise under stirring at room temperature to the 2-aminohydroquinone (4.16 g, 0.128 mole) in dry acetone (400 ml) and diethanolamine (2.04 ml, 0.128 mole). The reaction mixture was poured into water and hydrochloride acid (2,000 ml, pH 1), then extracted with ethylacetate (500 ml). The solvent was evaporated to dryness and the solid residue (4.20 g, 80%) was used without any further purification. The structure of the 2-(α-chloroacetamido)-hydroquinone was confirmed by NMR analysis.

출처