반응 #62944

반응 방정식

methyl 2-mercapto-4-methyl-1,3-thiazol-5-yl-acetate

methyl 2-bromomethylbenzoate

→

oil

수율 79.0%

Methyl [2-(2-methoxycarbonylbenzyl)thio-4-methyl-1,3-thiazol-5-yl]acetate

수율 79.0%

용매

DMF

potassium carbonate

반응 조건

후처리

1. 1
   workup.ADDITIONwere added dropwise
2. 2
   온도After the evolution of heat
3. 3
   여과filtered
4. 4
   기타DMF was removed in a rotary evaporator
5. 5
   세척washed 2× with water
6. 6
   기타The organic phase was dried
7. 7
   기타the solvent was removed in vacuo

실험 절차

4.1 g of methyl 2-mercapto-4-methyl-1,3-thiazol-5-yl-acetate were dissolved in 50 ml of DMF and, in the presence of 5 g of ground potassium carbonate, 5.1 g of methyl 2-bromomethylbenzoate were added dropwise. After the evolution of heat had subsided, the mixture was stirred for 1 h, filtered, and DMF was removed in a rotary evaporator. The residue was taken up in ethyl acetate and washed 2× with water. The organic phase was dried, and the solvent was removed in vacuo. 5.6 g of an oil were obtained.

출처