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benzaldehyde

4-pyridinecarboxaldehyde

acid ( 1 )

1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

→

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-pyridylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

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실험 절차

In the described fashion of Example 1 replacing benzaldehyde with 4-pyridinecarboxaldehyde and using the acid (1) (R=cyclopropyl) described in example 19 one obtains 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-pyridylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3); (R=cyclopropyl, Z=4-pyridine). mp 233°-234° C.

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