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benzaldehyde

p-fluorobenzaldehyde

acid ( 1 )

1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

→

1-o,p-difluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3(p-fluorobenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

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실험 절차

In the described fashion of Example 1 replacing benzaldehyde with p-fluorobenzaldehyde and using the acid (1) (R=o,p-difluorophenyl) described in Example 7, one obtains 1-o,p-difluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3(p-fluorobenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3) (R=o,p-difluorophenyl, Z=p-fluorophenyl).

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