반응 #62856

반응 방정식

2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

Na2S2O4

HCl

→

3-Amino-2-chloro-5-fluoro-4-methyl-benzoic acid

용매

water

glycol monomethyl ether

water

반응 조건

후처리

1. 1
   온도cooled
2. 2
   기타The solid which has precipitated
3. 3
   기타is isolated
4. 4
   기타dried

실험 절차

18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.

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