반응 #62839

반응 방정식

potassium hydroxide

3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid

glycine ethyl ester hydrochloride

triethylamine

→

title compound

수율 85.0%

N-(3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenoyl)-glycine

수율 85.0%

용매

ethanol

water

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도under reflux for 30 minutes
3. 3
   workup.ADDITIONwas added
4. 4
   추출the obtained aqueous solution was extracted with ethyl acetate
5. 5
   세척The ethyl acetate layer was washed with water
6. 6
   건조dried over magnesium sulfate
7. 7
   workup.DISTILLATIONThe solvent was distilled off

실험 절차

The reaction of 6.1 g of 3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid with glycine ethyl ester hydrochloride was conducted in the same manner as described in Example 1 except that 6.5 ml of triethylamine was used. Then, a solution of 2.7 g of potassium hydroxide in ethanol was added. The mixture was heated under reflux for 30 minutes. After the completion of the reaction, water was added and the obtained aqueous solution was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over magnesium sulfate. The solvent was distilled off to afford 6.1 g (yield 85%) of the title compound as a pale brown oil.

출처