반응 #62830

반응 방정식

5-fluoroisatin

triethylamine

methyl isocyanate

→

5-fluoro-1-methylcarbamoylisatin

수율 74.5%

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도cooling
2. 2
   workup.STIRRINGThe mixture is stirred at room temperature for 30 minutes
3. 3
   여과the precipitates are taken by filtration

실험 절차

A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.

출처