반응 #62823

반응 방정식

5,6-Dichloro-1-methylcarbamoylisatin

thiourea

triethylamine

→

6,7-dichloro-3-methyl-4-hydroxy-4-thioureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline

수율 33.4%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The resulting precipitates
2. 2
   여과are taken by filtration

실험 절차

5,6-Dichloro-1-methylcarbamoylisatin (9.6 g) is suspended in tetrahydrofuran (100 ml) and thereto are added thiourea (3.0 g) and triethylamine (5.6 ml), and the mixture is stirred at room temperature for 5 hours. The resulting precipitates are taken by filtration to give 6,7-dichloro-3-methyl-4-hydroxy-4-thioureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline (4.1 g). M.p. 225-228° C.

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