반응 #62799

반응 방정식

4-aminomethyl-1-benzylpyrrolidin-2-one

p-chlorophenylisocyanate

→

title compound

수율 74.9%

4-(p-Chlorophenylamino-carbonylaminomethyl)-1-benzylpyrrolidin-2-one

수율 74.9%

용매

dioxane

반응 조건

후처리

1. 1
   기타the solution is then evaporated in vacuo
2. 2
   기타The residue crystallizes out of ethyl acetate

실험 절차

52 g (0.25 mol) of 4-aminomethyl-1-benzylpyrrolidin-2-one are stirred for 2 hours at ambient temperature in 70 ml of dioxane with 38 g (0.25 mol) of p-chlorophenylisocyanate and the solution is then evaporated in vacuo. The residue crystallizes out of ethyl acetate to yield 67 g of the title compound, m.p. 139°-140° C.

출처