반응 #6272

반응 방정식

4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine

hydrochloric acid methanol

→

desired compound

수율 85.6%

4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine dihydrochloride

수율 85.6%

용매

methanol

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   기타the residue was purified by recrystallization (solvent: ethanol-ether)

실험 절차

To a solution of 704.5 mg (2.57 mmol) of 4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine in 30 ml of methanol, 70 ml of 10% hydrochloric acid-methanol was added, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off and the residue was purified by recrystallization (solvent: ethanol-ether) to give 842.4 mg of the desired compound (85.6% yield, pale yellow crystals).

출처