반응 #626544

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N-(6-Bromo-2-(tetrahydro-2H-pyran-3-yl)chroman-4-ylidene)-2-methylpropane-2-sulfinamide

2-oxopropanethioamide

Intermediate 2

2-oxopropanethioamide

→

crude title compound

6-Bromo-4′-methyl-2-(tetrahydro-2H-pyran-3-yl)spiro[chroman-4,2′-imidazole]-5′(1′H)-thione

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The vial was sealed
2. 2
   기타The solvent was evaporated

실험 절차

N-(6-Bromo-2-(tetrahydro-2H-pyran-3-yl)chroman-4-ylidene)-2-methylpropane-2-sulfinamide (Example 47 Step 1, 0.5 g, 1.21 mmol) and 2-oxopropanethioamide (Intermediate 2, 0.373 g, 3.62 mmol) were dissolved in dry acetonitrile (4.0 mL) in a dry microwave vial. The vial was sealed and heated with MW for 20 min. at 130° C. The solvent was evaporated to give the crude title compound that was used directly in the next reaction. MS (ES+) m/z 395 [M+H]+.

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