반응 #6264

반응 방정식

2,4-thiazolidinedione

benzaldehyde

piperidine

→

desired compound

수율 90.4%

5-benzylidene-2,4-thiazolidinedione

수율 90.4%

용매

ethanol

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도under reflux for 5 hours
3. 3
   온도After cooling
4. 4
   여과the precipitated crystals were filtered
5. 5
   세척washed with cooled ethanol

실험 절차

To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of benzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 31.67 g of the desired compound (90.4% yield, pale yellow crystals).

출처