반응 #62582

반응 방정식

dl-2-amino-1-propanol

hexadecanoyl chloride

→

title compound

수율 51.0%

2-(N-Hexadecanoyl)amino-1-propanol

수율 51.0%

용매

CH2Cl2

반응 조건

후처리

1. 1
   농축The solution was concentrated
2. 2
   기타decanted
3. 3
   농축The solution was concentrated
4. 4
   기타the residue was chromatographed on silica gel using 50% ethylacetate in hexane

실험 절차

A solution of 4.00 g (53.2 mmol) of commercially obtained dl-2-amino-1-propanol b and 8.0 g (8.8 ml, 29.3 mmol) of hexadecanoyl chloride in 100 ml of CH2Cl2 was stirred at room temperature for hours. The solution was concentrated and the residue was boiled with 200 ml acetone and decanted. The solution was concentrated and the residue was chromatographed on silica gel using 50% ethylacetate in hexane to afford 4.15 g (51%) of the title compound as white needles, m.p. 75-76° C. Using the same procedure as in Example 19, the following compounds were prepared:

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