반응 #6258

반응 방정식

4-(4-phthalimidobutyloxy)pyridine

hydrogen chloride methanol

→

desired compound

수율 86.3%

4-(4-phthalimidobutyloxy)pyridine hydrochloride

수율 86.3%

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISSOLUTIONdissolve
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   기타the residue was crystallized from acetone-ether
5. 5
   여과The resulting crystals were collected by filtration
6. 6
   세척washed with ether

실험 절차

To a suspension of 1.48 g (5.0 mmol) of 4-(4-phthalimidobutyloxy)pyridine in 20 ml of methanol, 15 ml of hydrogen chloride-methanol was added and dissolve. The solvent was distilled off and the residue was crystallized from acetone-ether. The resulting crystals were collected by filtration and washed with ether to give 1.51 g of the desired compound (86.3% yield, colorless crystals), mp. 154°-156° C.

출처