반응 #62560
ord-16963ddea0f6455db41136801f58d750
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후처리
- 1기타the aqueous phase is separated off
- 2세척the organic layer is washed in succession with 5% aqueous citric acid and 8% aqueous NaHCO3 solution
- 3기타dried
- 4농축concentrated by evaporation
- 5기타After purifying by chromatography
실험 절차
At 0°, 24 ml of 1N NaOH, 820 mg of tetrabutylammonium bisulphate and 1 ml of chloroformic acid allyl ester are added to a solution of 2 g of (3S,4S)-1-(p-methoxybenzyl)-3-[(1R)-1-hydroxyethyl)-4-tert.-butoxycarbonyl-2-azetidinone in 24 ml of methylene chloride and the whole is stirred vigorously. After a reaction time of 20 and 40 minutes, further portions (each of 1 ml) of chloroformic acid allyl ester are added. The reaction mixture is diluted with methylene chloride, the aqueous phase is separated off and the organic layer is washed in succession with 5% aqueous citric acid and 8% aqueous NaHCO3 solution and then dried and concentrated by evaporation. After purifying by chromatography, the pure, amorphous title compound is obtained.