반응 #62548

반응 방정식

Methyl chloroacetate

N-methylpiperazine

→

2-(4-methyl-1-piperazinyl)acetic acid, methyl ester

수율 95.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   기타the solvent was removed under vacuum
3. 3
   workup.DISSOLUTIONThe resulting oil was dissolved in methylene chloride-methanol (9:1)
4. 4
   기타purified by flash chromatography (silica)

실험 절차

Methyl chloroacetate (8.8 ml., 0.10 mole) was added to a solution of N-methylpiperazine (24.4. ml., 0.22 mole) in ethyl acetate (140 ml.) and the mixture was stirred for 17 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting oil was dissolved in methylene chloride-methanol (9:1) and purified by flash chromatography (silica) to give 2-(4-methyl-1-piperazinyl)acetic acid, methyl ester as an oil (16.3 g, 95%).

출처