반응 #62482

반응 방정식

6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline

pentafluorophenyl-tetramethyluronium hexafluorophosphate

diisopropylethylamine

(R)-2-ethyloxycarbonyl-pyrrolidine

→

6-chloro-4-[(1R/S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-[(2R)-2-ethoxycarbonyl-pyrrolidin-1-yl-carbonyl]-quinazoline

용매

DMSO

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실험 절차

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and (R)-2-ethyloxycarbonyl-pyrrolidine in DMSO at ambient temperature.

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