반응 #62436

반응 방정식

6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline

2-(4-methyl-piperazin-1-ylmethyl)-piperidine

TBTU

trifluoroacetic acid

→

6-chloro-4-{1-(5-chloro-1H-benzimidazol-2-yl)-3-[2-(4-methyl-piperazin-1-ylmethyl)-piperidin-1-yl-carbonyl]-propyl-amino}-7-(pyrrolidin-1-yl-carbonyl)-quinazoline

용매

acetonitrile tetrahydrofuran

반응 조건

실험 절차

Prepared analogously to Example 61 from 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and 2-(4-methyl-piperazin-1-ylmethyl)-piperidine with TBTU in acetonitrile/tetrahydrofuran and subsequent reaction with trifluoroacetic acid.

출처