반응 #62386

반응 방정식

ethanol

3-iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile

lithium hydroxide

hydrochloric acid

→

title compound

3-Iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carboxylic acid

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for a day
3. 3
   여과the precipitated crystals were collected by filtration
4. 4
   세척The crystals were washed successively with water and diethyl ether

실험 절차

To a suspension of 3.0 g of 3-iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile obtained by Production example 431 in 20 mL of ethanol was added 20 mL of 4N lithium hydroxide aqueous solution at room temperature, and heated at reflux for a day. After cooling to room temperature, the solution was neutralized with 5N hydrochloric acid aqueous solution, and the precipitated crystals were collected by filtration. The crystals were washed successively with water and diethyl ether, to afford 3.0 g of the title compound as colorless crystals.

출처