반응 #62381

반응 방정식

oxazole 2-carboaldehyde

tert-butyl carbamate

sodium p-toluenesulfonate

formic acid

→

title compound

수율 24.7%

[Oxazol-2-yl-(toluene-4-sulfonyl)-methyl]-carbamic acid tert-butyl ester

수율 24.7%

용매

methanol

water

반응 조건

후처리

1. 1
   여과The precipitated crystals were collected by filtration
2. 2
   세척washed with water
3. 3
   기타dried under reduced pressure

실험 절차

300 mg of oxazole 2-carboaldehyde was dissolved in a mixed solvent of 3 mL of methanol and 6 mL of water, added successively with 363 mg of tert-butyl carbamate, 552 mg of sodium p-toluenesulfonate and 0.76 mL of formic acid and stirred at room temperature for 16 hours and 30 minutes. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure, to afford 247 mg of the title compound as colorless crystals.

출처