반응 #62373

반응 방정식

1-(tert-butoxycarbonyl-methyl-amino)-cyclopropane carboxylic acid ethyl ester

water

→

title compound

수율 84.8%

1-(tert-Butoxycarbonyl-methyl-amino)-cyclopropane carboxylic acid

수율 84.8%

용매

methanol

sodium hydroxide

반응 조건

후처리

1. 1
   세척the reaction solution was washed with diethyl ether
2. 2
   workup.ADDITIONThe aqueous layer was added with 0.7 mL of 1N hydrochloric acid
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The organic layer was washed with saturated brine
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타The solvent was evaporated

실험 절차

To a solution of 48 mg of 1-(tert-butoxycarbonyl-methyl-amino)-cyclopropane carboxylic acid ethyl ester in 0.4 mL of methanol, 0.1 mL of 5N sodium hydroxide aqueous solution was added and stirred at room temperature overnight. After adding water, the reaction solution was washed with diethyl ether. The aqueous layer was added with 0.7 mL of 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated, to afford 36 mg of the title compound as white crystals.

출처