반응 #62351

반응 방정식

5-chloro-4-hydroxymethylthiophene-2-carbonitrile

Dess-Martin reagent

→

crude product

수율 151.8%

5-Chloro-4-formylthiophene-2-carbonitrile

수율 151.8%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척washing successively with aqueous sodium hydrogen carbonate and saturated brine
2. 2
   건조drying over anhydrous magnesium sulfate
3. 3
   기타the solvent was evaporated

실험 절차

To a solution of 3.0 g of 5-chloro-4-hydroxymethylthiophene-2-carbonitrile in 34 mL of dichloromethane was added 8.06 g of Dess-Martin reagent at room temperature, and stirred at this temperature for a day. After diluting with dichloromethane, washing successively with aqueous sodium hydrogen carbonate and saturated brine, and drying over anhydrous magnesium sulfate, the solvent was evaporated, to afford 4.5 g of a crude product of the title compound as colorless crystals.

출처