반응 #62307

ord-01a90d08fb0a473ea7da21d086405516

반응 방정식

Nc1cc(F)c2[nH]nc(/C=C/c3cccnc3)c2c1
7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine
O=C(O)c1ccco1
2-furancarboxylic acid
O=C(Nc1cc(F)c2c(c1)c(/C=C/c1cccnc1)nn2C(=O)c1ccco1)c1ccco1
title compound
수율 37.9%
O=C(Nc1cc(F)c2c(c1)c(/C=C/c1cccnc1)nn2C(=O)c1ccco1)c1ccco1
Furan-2-carboxylic acid{7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide
수율 37.9%

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타with the method of Example 127, purification by LC-MS

실험 절차

Following amidation using 217 mg of 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine and 286 mg of 2-furancarboxylic acid in accordance with the method of Example 127, purification by LC-MS was carried out, to afford 143 mg of the title compound as yellow crystals.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07429609B2uspto-grants-2008_09