반응 #622796

반응 방정식

4-chlorophthalazin-1(2H)-one

sodium 2-methylpropane-2-thiolate

K2CO3

→

title compound

수율 20.0%

4-(tert-butylthio)phthalazin-1(2H)-one

수율 20.0%

용매

EtOAc

반응 조건

후처리

1. 1
   세척washed with saturated aqueous NaHCO3
2. 2
   건조dried (Na2SO4)
3. 3
   여과filtered
4. 4
   기타chromatographed (0-30% EtOAc/DCM)

실험 절차

A mixture of 4-chlorophthalazin-1(2H)-one (200 mg, 1.11 mmol), sodium 2-methylpropane-2-thiolate (248 mg, 2.22 mmol), tris(trifluoromethylsulfonyloxy)scandium (54.5 mg, 0.11 mmol) and K2CO3 (308 mg, 2.22 mmol) was heated at 160° C. under microwave condition for 30 minutes. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO3, dried (Na2SO4), filtered, and chromatographed (0-30% EtOAc/DCM) to give 52 mg (20%) of the title compound as a white solid: MS (DCI) 235 (M+H).

출처