반응 #62166

반응 방정식

water

2-Chloromethyl-quinoline

4-Hydroxy-benzamide

cesium carbonate

→

title compound

수율 45.0%

4-(Quinolin-2-ylmethoxy)-benzamide

수율 45.0%

용매

dimethyl formamide

반응 조건

후처리

1. 1
   추출extracted with chloroform, dried magnesium sulfate
2. 2
   여과filtered
3. 3
   농축concentrated

실험 절차

To a solution of 2-Chloromethyl-quinoline (1.57 g) and 4-Hydroxy-benzamide (995 mg) in dimethyl formamide (20 mL) was added cesium carbonate (7.3 g) and the reaction mixture heated at 80° C. for 18 h. The reaction mixture was poured into water and extracted with chloroform, dried magnesium sulfate, filtered and concentrated to provided the title compound (909 mg). MS: (M+H -m/z=279.3).

출처