반응 #62144

반응 방정식

4-(2-Quinolin-2-yl-ethyl)-benzoic acid

acetonitrile

O,N-Dimethyl-hydroxylamine hydrogen chloride

sodium hydroxide

→

title compound

수율 88.0%

N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide

수율 88.0%

용매

dioxane

triethylamine

반응 조건

후처리

1. 1
   추출extracted with chloroform, dried magnesium sulfate
2. 2
   여과filtered
3. 3
   농축concentrated
4. 4
   세척Biotage MPLC chromatography eluting with 20-50% ethyl acetate

실험 절차

To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid (530 mg) in dioxane 5 ml/acetonitrile 5 ml was added triethylamine (0.60 ml) and O,N-Dimethyl-hydroxylamine hydrogen chloride (240 mg). After 72 h, the reaction mixture was poured into 1N sodium hydroxide solution and extracted with chloroform, dried magnesium sulfate, filtered and concentrated. Biotage MPLC chromatography eluting with 20-50% ethyl acetate provided the title compound (516 mg, 88%). MS: (M+H m/z=321.1).

출처