반응 #62093

반응 방정식

Methyl 2-chloro-3-{4-[2-(4-hydroxyphenoxy)ethyl]phenyl}propanoate

triethylamine

Methanesulfonyl chloride

→

pure product

수율 96.0%

Methyl 2-chloro-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoate

수율 96.0%

용매

dichlormethane

dichlormethane

반응 조건

후처리

1. 1
   기타to reach room temperature
2. 2
   세척the mixture was washed (water, brine)
3. 3
   건조dried (Na2SO4)
4. 4
   기타evaporated under reduced pressure

실험 절차

Methyl 2-chloro-3-{4-[2-(4-hydroxyphenoxy)ethyl]phenyl}propanoate (334 mg, 1.0 mmol) and triethylamine (303 mg, 3.0 mmol) was dissolved in 20 ml dichlormethane and cooled to −20° C. under nitrogen atmosphere. Methanesulfonyl chloride (114 mg, 1.0 mmol) was added dropwise. The mixture was allowed to reach room temperature. After 2 hours dichlormethane was added, the mixture was washed (water, brine), dried (Na2SO4) and evaporated under reduced pressure to yield 394 mg pure product (yield 96%).

출처