반응 #61975

반응 방정식

sodium bicarbonate

4-hydroxybenzaldehyde

piperidine

sodium triacetoxyborohydride

→

title compound

4-Piperidin-1-ylmethyl-phenol

용매

DCE

acetic acid

반응 조건

후처리

1. 1
   추출extracted with DCM (5×100 mL)
2. 2
   건조The combined organic phases were dried (magnesium sulfate)
3. 3
   기타evaporated

실험 절차

A solution of 4-hydroxybenzaldehyde (10 g), piperidine (8.9 mL), and acetic acid (4.7 mL) in DCE (200 mL) was treated with sodium triacetoxyborohydride (24 g). After 16 h, the resulting mixture was treated with saturated aqueous sodium bicarbonate (100 mL) and extracted with DCM (5×100 mL). The combined organic phases were dried (magnesium sulfate) and evaporated. Trituration of the residue with ethyl acetate gave the title compound as a white crystalline solid (5.5 g).

출처