반응 #619116

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1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

(carbethoxymethylene)triphenylphosphorane

THF

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

수율 69.0%

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후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   기타the residue was purified by flash chromatography (silica, CH2Cl2-EtOAc, 4:1)

실험 절차

A solution of 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (Example 252) (90 mg, 0.27 mmol) and (carbethoxymethylene)triphenylphosphorane (102 mg, 0.30 mmol) in THF (5 mL) was stirred at 40° C. for 12 h. The reaction mixture was concentrated and the residue was purified by flash chromatography (silica, CH2Cl2-EtOAc, 4:1) to obtain 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (75 mg) in 69% yield.

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