반응 #619087

반응 방정식

water

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea

NCS

→

3-(5-Chloro-thiazol-2-yl)-1-cyclohexyl-1-piperidin-1-yl-urea

용매

DCM

DCM

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   건조The organic phase was dried (MgSO4)
3. 3
   기타the solvent was removed in vacuo
4. 4
   workup.ADDITIONMeCN (1 mL) was added whereupon the product
5. 5
   기타precipitated
6. 6
   여과The product was filtered off
7. 7
   기타dried

실험 절차

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea (50 mg, 0.16 mmol), prepared in an identical manner to Example 94 was dissolved in DCM (1 mL) and NCS (26 mg, 0.19 mmol)) was added. The reaction mixture was stirred for 3 days before DCM (20 mL) and water (20 mL) was added. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. MeCN (1 mL) was added whereupon the product precipitated. The product was filtered off and dried. Yield: 20 mg.

출처